Figure 6.
Fig. 6. Computational study of the effects of swapping
residues from RasGRF1 and Sos. The number of times a given
residue accumulated a conformation-stabilizing mutation in
low-energy sequences from 100 separate Monte Carlo simulations
is described by the substitution frequency. (a and b) C[ ]positions for buried
residues that are swapped with high frequency are indicated
(spheres) for Sos (a) and RasGRF1 (b). (c and d) Several Sos
residues that substitute with high frequency are located in the
flap1-helical hairpin interface (see also Fig. 5). (c) Wild-type
Sos. (d) Substitutions from RasGRF1.
]positions for buried
residues that are swapped with high frequency are indicated
(spheres) for Sos (a) and RasGRF1 (b). (c and d) Several Sos
residues that substitute with high frequency are located in the
flap1-helical hairpin interface (see also Fig. 5). (c) Wild-type
Sos. (d) Substitutions from RasGRF1.