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Figure 6.
Figure 6. Model of ATP-Dependent Peptide Transport
Two
opposing models are discussed. In model 1, the preferred
model, peptide binding stimulates a conformational change in
TAP2-NBD, facilitating ATP binding and NBD dimerization. This is
coupled to peptide transport. In model 2, the NBDs have
instrinsic ability to form an ATP-dependent dimer, and peptide
binding stimulates ATP hydrolysis and NBD dissociation, which
drives peptide translocation. TAP1 is green, TAP2 is blue, and
peptide is red.
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