Figure 6 - full size

 

Figure 6.
Figure 6 Schematic representation of the reaction steps proposed for RNase H. The substrate RNA is shown in pink and products in purple. Coordination of metal ions is highlighted in dark blue, and scissile phosphate in red. Selected hydrogen bonds are shown as blue lines. Black circles represent water molecules. The distance between the two metal ions is indicated in the enzyme–substrate, enzyme–intermediate and enzyme–product complexes.

The above figure is reprinted by permission from Macmillan Publishers Ltd: EMBO J (2006, 25, 1924-1933) copyright 2006.