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Figure 6.
Figure 6. The ELKS1bC peptide binds to a narrow and deep groove
of the RIM1α PDZ domain. (a)–(d) Surface representations of
(a) the RIM1α PDZ domain, (b) the third PDZ domain of PSD-95,
(c) the sixth PDZ of GRIP1 and (d) the PDZ domain of nNOS,
complexed with target peptides (the PDB accession numbers are
1be9, 1n7f and 1b8q for (b)–(d), respectively). The surfaces
of the PDZ domains are represented in blue, and the bound
peptides are shown as stick models with the P[0], P[−1],
P-[−2], and P[−3] residues colored pink, red, yellow and
orange, respectively. The side-chains that form the top surface
of the groove in the RIM1α PDZ domain are labeled in (a). The
models were prepared with Pymol (DeLano Scientific, San Carlos,
CA; http://pymol.sourceforge.net/). Figure 6. The ELKS1bC
peptide binds to a narrow and deep groove of the RIM1α PDZ
domain. (a)–(d) Surface representations of (a) the RIM1α PDZ
domain, (b) the third PDZ domain of PSD-95, (c) the sixth PDZ of
GRIP1 and (d) the PDZ domain of nNOS, complexed with target
peptides (the PDB accession numbers are 1be9, 1n7f and 1b8q for
(b)–(d), respectively). The surfaces of the PDZ domains are
represented in blue, and the bound peptides are shown as stick
models with the P[0], P[−1], P-[−2], and P[−3] residues
colored pink, red, yellow and orange, respectively. The
side-chains that form the top surface of the groove in the
RIM1α PDZ domain are labeled in (a). The models were prepared
with Pymol (DeLano Scientific, San Carlos, CA;
http://pymol.sourceforge.net/).
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