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Figure 6.
FIG. 6. Superposition of 3CLpro active sites and
inhibitors. A, superimposition of the active site of five 3CLpro
protease structures: cyan and blue, protomer A and B of C145A;
light green and gold, protomer A and B of the wild type,
respectively; crimson, HCoV 229E 3CLpro (1P9S); and pink, TGEV
3CLpro (1P9U). B, superimposition of the six C-terminal residues
of SARS 3CLpro (SGVTFQ) (cyan), the inhibitor of TGEV 3CLpro
(1P9U, pink), the inhibitor of TGEV 3CLpro (VNSTLQ) at the
active site of SARS 3CLpro (1UK4, gold), and the inhibitor of
Rhinovirus 3CLpro, AG7088 at the active site (1CQQ, green).
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