Figure 7 - full size

 

Figure 7.
Figure 7. Schematic of Gating ModelTwo of the four CNB domains are shown attached to the last transmembrane helices. The open and closed states correspond to liganded and unliganded structures, respectively. Arrows indicate the direction of movement to attain the structure shown, from the alternate conformation. The orientation of the domains relative to the transmembrane helices is arbitrary.

The above figure is reprinted by permission from Cell Press: Cell (2004, 119, 615-627) copyright 2004.