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Figure 6.
Figure 6. Models of Fibrillin-1 and Microfibril
Organization(A) Homology model for cbEGF11-TB5. cbEGF and TB
domains are colored green and blue, respectively. The crystal
structure of cbEGF22-TB4-cbEGF23 fragment is highlighted in
bold. Ca^2+ and potential N-linked glycosylation sites are
represented by red and black spheres, respectively. The RGD
motif on the TB4 loop is indicated.(B) A simple model of the
fibrillin microfibril. The arrows represent fibrillin-1
molecules with dimensions based on the knowledge of the
component domains. The intermolecular transglutaminase
cross-links are shown as X and the associated protein MAGP-1 as
a turquoise diamond. A sketch of the STEM data of Baldock et al.
(2001) is shown below. The colored regions mark the sites of
known antibody epitopes (red, 2502; green, 11C1.3; purple, PF2;
yellow, 2499). The bead regions are shown as gray ellipses.
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