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Figure 6.
FIG. 6. Comparison of inhibitor binding to COX-2. a,
superposition of the structures of diclofenac (green) and
indomethacin (gold carbons; Protein Data Bank number 4COX [PDB]
) shows their differential coordination to the protein, despite
their comparable size and chemical composition. b, overlay of
the structures of diclofenac and the inhibitory mode of
arachidonic acid binding. Both ligands coordinate their acidic
groups with the side chains of Tyr-385 and Ser-530 despite their
dissimilar chemical structures.
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