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Figure 6.
Figure 6. A Model for Insensitivity of PDE7 to Rolipram
Inhibition(A) The hydrogen bonds (dotted lines) between Gln369
and rolipram in PDE4.(B) The correspondence of residues Ser373,
Ser377, and Gln413 in PDE7A to Tyr329, Thr333, and Gln369 in
PDE4D2 may lead Gln413 to adopt a new conformation to form a
hydrogen bond with Ser377. As a result, Gln413 would not be
capable of forming hydrogen bonds with rolipram. The orange
sticks mark the side chain conformation of Gln369 in PDE4.
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