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Figure 6.
Fig. 6. Mechanism of agonist binding and domain closure.
(A) The binding site of the open-cleft, closed-channel state
(Apo S1S2J, protomer A). (B) The possible first step in agonist
binding as observed in molecule B of the L650T/AMPA(AS)
structure. We suggest that this semiclosed cleft conformation
represents the agonist-bound, closed-channel state. (C) The
closed-cleft, open-channel conformation as observed in the WT
S1S2J/AMPA binding cleft (protomer A). In B and C, water
molecules are shown as green spheres, AMPA is drawn in magenta,
and hydrogen bonds are depicted by black dashed lines. The
degrees of domain closure relative to the Apo conformation are
indicated below each structure.
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