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Figure 6.
Fig. 6. Surface representations illustrating the binding
surfaces involved in the IIA^Mtl-HPr (left panel), IIA^Glc-HPr
(middle panel), and EIN-HPr (right panel) complexes. The binding
surfaces on IIA^Mtl, IIA Glc, and EIN are shown in A, and the
binding surfaces on HPr are shown in B. The binding surfaces are
color-coded with hydrophobic residues in green, polar residues
in light blue, the active site histidines in purple, positively
charged residues in dark blue, and negatively charged residues
in red. The relevant portions of the backbone of HPr are shown
in gold in A; the relevant portions of the backbone of IIA^Mtl,
IIA^Glc, and EIN are shown in blue, red, and green,
respectively, in B. The location of the phosphoryl group in the
transition state is depicted in yellow. Residues of HPr are
labeled in italics. The coordinates of the EIN-HPr and
IIA^Glc-HPr complexes are taken from Garrett et al. (16) (code
3EZE) and Wang et al. (17) (code 1GGR), respectively.
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