|
Figure 6.
Figure 6. Implications for RSK-Mediated Signaling(A)
Proposed mechanisms of Smad2 dissociation from the receptor
kinase (TβRI) (Huse et al., 1999) after phosphorylation. The
positively charged loop-strand pocket on Smad2, which is
responsible for binding the phosphorylated C terminus of another
Smad2, coincides with the L3 loop region, which is involved in
interactions with the L45 loop and the GS region of the receptor
kinase. The mutual exclusion is proposed to lead to dissociation
of phosphorylated Smad2 from the receptors.(B) A schematic
diagram of signal flow in the RSK-mediated signaling,
highlighting the MH2 domain as the pSer binding motif.
|
