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Figure 6.
Fig. 6. a: Structure and (2|F[o]|−|F[c]|), α[c] map
for uPA–APC-11092, 1.80 Å resolution. The long
N1–Oδ2[Asp189] and N2–Oδ2[Asp189] interactions (3.17
Å and 3.40 Å, respectively, at pH 6.5) are shown in
yellow and transparent light yellow, respectively. b: Structure
and (2|F[o]|−|F[c]|), α[c] map for uPA–APC-10950, 1.64
Å resolution. The H[2]O1[S1]–F hydrogen bond (2.76
Å) is formed at the expense of the H[2]O1[S1]–O[Trp215]
interaction, the length of which increases from 3.07 Å in
uPA–APC-8696 to 3.52 Å in uPA–APC-10950 (Table 3c).
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