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Figure 6.
Figure 6. Flexible Domain Organization of CBP/p300Schematic
diagram illustrating how flexible tethers may permit CBP/p300
molecules to adapt to different enhancers. Binding of ligands
can indirectly modify acetyltransferase activity by causing
domain rearrangements. Two mechanisms by which phosphorylation
of a ligand regulates its binding to CBP/p300 are also shown
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