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Figure 6.
Fig. 6. Antibody-Fc  RIII
binding and ligand induced receptor aggregation model. A, an
intact antibody-Fc RIII
binding model. The structure of the antibody is shown in magenta
and that of Fc RIII is in
green. The position of the second possible orientation of Fc
RIII, which
is in direct steric conflict with the hinge region and Fab, is
indicated by a blue-shaded area. The arrow points to the
location of the lower hinge (L.H.). The Protein Data Bank entry
for the antibody coordinates is 1IGT. B, a simple avidity model
of antigen-antibody binding induced Fc RIII
aggregation. C, an ordered receptor aggregation model.
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