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Figure 6.
Figure 6. Surface representation of the cruzain active-site
region. Hydrophobic residues are indicated in green. (Note that
the sides of the S2 pocket are lined with hydrophobic patches.)
The surfaces of amino acids of interest (see text) are labeled
and color coded: Gln19 and His159, cyan; Asp158 and Ser139,
magenta; Cys25 and Met142, yellow. Inhibitor molecules are
displayed as sticks. (a) VSI, (b) VSII, (c) VSIII, (d) VSIV.
This figure was prepared with the program GRASP [44].
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