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Figure 6.
Fig. 6. o-Carboxy group interactions. A, identical
protein atoms in the Tyr(P)·C215S PTP1B complex and the
compound 1·PTP1B complex are superimposed. The Tyr(P) is
in orange, the Tyr(P)/C215S PTP1B protein is in red, compound 1
is in white, and the PTP1B protein interacting with compound 1
is in yellow. B, the hydrogen bonding network around the
o-carboxy group of compound 1; atoms are colored according to
atom type (carbon in white, oxygen in red, nitrogen in blue, and
iodine in green). Hydrogen bonding lengths are given in Å.
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