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Figure 6.
Fig. 6. Model of the scD10-SEB-pMHCII interaction complex. (A)
Superposition of the V  C -SEB
complex (in dark blue) and the scD10-CA/I-A^k complex. The V
domains
from each complex were used for least-square fitting (92 C  atoms from
residues Val3-Gly94 of V , rmsd =
0.67 Å). The color scheme for the complex of D10-CA/I-A^k
is as labeled. (B) The superposition of the SEB/HLA-DR1 complex
(in brown) to the already superimposed V C -SEB
complex (in dark blue) and scD10 (V V ) module
derived from (A). The two SEB superantigen molecules were used
for least-square fitting (83 C atoms,
rmsd = 0.63 Å). (C) scD10-SEB-CA/I-A^k interaction
complex. DR1 in Fig. 6B has been replaced with I-A^k on the
basis of structural alignment of residues of the two helices of
each MHC molecule (43 C atoms,
rmsd = 1.02 Å).
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