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Figure 6.
Figure 6. Interactions of Phospho-Phosducin and G[t]α with
G[t]βγ(A) Ribbon diagram of the phosducin/G[t]βγ complex
where residues 67–86, which become disordered upon Ser-73
phosphorylation, are colored cyan. The N-terminal domain of
phosducin is purple, with its 30-residue flexible loop in
green. The C-terminal domain is blue. G[t]β is gold, and G[t]γ
is silver.(B) The transducin heterotrimer ([14]) with G[t]α in
red, the GDP in black, and G[t]βγ colored as in (A). Residues
67–86 in phosducin overlap the G[t]α-G[t]βγ interaction
surface.(C) Ribbon diagram (stereo pair) of the
phosducin/G[t]βγ interface near Helix 2. Residues involved in
the interactions with phosducin segment from Arg-67 to Asp-86
are shown in ball-and-stick representations. Phosducin residues
are labeled with purple or cyan symbols, and G[t]βγ residues
with black symbols. The complex is viewed in the same “top”
orientation in all three panels.
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