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Figure 6.
Figure 6. Possible Mechanism for EVH1 Domain Targeting of
Actin Assembly(A) EVH1 proteins may recognize proline-rich
peptides (solid rectangle) in an acidic phospholipid context to
selectively localize to leading edge membrane sites.(B)
Pathogens such as Listeria monocytogenes may use peptide ligand
sequences that emulate the combination of interactions described
in (A). The ActA sequences have a high density of negatively
charged residues immediately C-terminal to the peptide’s
proline-rich core peptide sequence. Such ligands have higher
affinity than host-derived ligands and may constitutively
recruit EVH1 domain proteins in a nonmembrane context (e.g.,
outside of the cell wall of the gram-positive bacteria).
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