Figure 6.
Figure 6 Proposed scheme of the effect of calcium on
membrane-clustered E-cadherin. Low Ca^2+ concentrations
stabilize the rod-like structure (A and B), medium and high
concentrations result in cis-dimerization (C) and Trp2 docking
in its hydrophobic cavity which enables trans-interaction (D).
Domains 1–5 are drawn as gray blocks, with the hydrophobic
cavity to which Trp2 binds in domain 1. Trp2 is shown as a green
symbol with the A-strand
as a connecting black line. Bound Ca^2+ ions are symbolized by
circles and the different K[d] values of the distinct binding
sites by different colors: blue, 30 M;
red, 330 M;
yellow, 2 mM.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(1999,
18,
1738-1747)
copyright 1999.
A-strand
as a connecting black line. Bound Ca^2+ ions are symbolized by
circles and the different K[d] values of the distinct binding
sites by different colors: blue, 30 
M;
red, 330