Figure 5.
Figure 5 A ball-and-stick representation30 of the active-site
residues of SPase 2-75
with the P1-P4 residues of an acylated peptide substrate
(Ala-Ala-Ala-Ala) modelled into the bindings sites S1-S4. The
observed positions of the methyl group (C16) and the carbonyl
oxygen (O8) of the inhibitor (Fig. 4) were used as a guide.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(1998,
396,
186-190)
copyright 1998.
2-75
with the P1-P4 residues of an acylated peptide substrate
(Ala-Ala-Ala-Ala) modelled into the bindings sites S1-S4. The
observed positions of the methyl group (C16) and the carbonyl
oxygen (O8) of the inhibitor (Fig. 4) were used as a guide.