|
Figure 5.
Figure 5. Solution structure of MIT1. (a) Backbone and
disulphide-bridge heavy atoms from residues 5 to 80 of the 39
NMR conformers (calculations rMD, Table 1). N, C and C^a atoms
from residues 6 to 79 of each structure were superimposed on the
average structure atoms. Central core residue backbone atoms (5
to 10, 16 to 21, 29 to 43, 57 to 69 and 75 to 80) are displayed
in blue, extremity residue backbone atoms of each finger (11 to
15, 22 to 28, 44 to 56 and 70 to 74) are displayed in red, and
disulphide-bridges in yellow. (b) Stereo view of the conformer
closest to the mean structure of the 39 conformers shown in (a).
The following colours were used for the side-chains: blue, Arg
and Lys; red, Glu and Asp; yellow, Ala, Cys, Ile, Leu, Met, Phe,
Pro, Trp and Val; grey, Asn, Gln, Ser, Thr and His. Buried
side-chains of the inner ionic bridge; Asp10 and Arg54 are
displayed with a thicker stick and are labelled. The His46 O
atom is labelled.
|
