Figure 5 - full size

Figure 5. Fig. 5. Electrostatic surface potentials of trypsins. Electrostatic potential of the surfaces of salmon (left), bovine (middle) and rat (right) trypsins. Potentials are taken from the PDB files. The P3­P4¢ binding loops of BPTI illustrates the binding of Lys15I in the specificity pockets and the different orientations of the Arg17I side chain (to the right). The figure also shows that the binding cleft of salmon trypsin is more open than for the mammalian enzymes due to the different fold of the autolysis loop. The figure was prepared using GRASP [37].

The above figure is reprinted by permission from the Federation of European Biochemical Societies: Eur J Biochem (1998, 256, 317-324) copyright 1998.