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Figure 5.
Figure 5. Fifty per cent inhibitory concentrations (IC50)
for Ca
2+
-CaM dependent activation of phosphodiester-
ase by W-7 derivatives containing a different substituent
atom at position 5: W-7(H), W-7(F), W-7, W-7(Br), and
W-7(I) (Tanaka et al., 1982; MacNeil et al., 1988). IC50 is
plotted against van der Waals radius and electronegativ-
ity (inset) for halogen atoms and hydrogen.
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