Figure 5.
Figure 5 N15 CDR3 residues involved in recognition of the
VSV8/Kb antigen -MHC class I complex. The figure is shown as a
GRASP (Nicholls et al., 1991) molecular surface representation,
viewing the ligand binding surface of the TCR. The V domain
is shown in blue-grey and the V domain
is shown in pink. Individual CDR3 and
residues,
whose mutation to alanine results in 1000-fold
reduction in sensitivity of T cell hybridoma transfectants to
varying molar concentrations of VSV8 peptide pulsed onto R8
antigen presenting cells, are shown in red. The CDR3 Asn101
residue which reduces recognition 100 fold is shown in yellow
and the CDR3 Glu105
residue, which has no detectable effect on recognition, is shown
in green.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
Embo J
(1998,
17,
10-26)
copyright 1998.
domain
is shown in blue-grey and the V 
domain
is shown in pink. Individual CDR3 
1000-fold
reduction in sensitivity of T cell hybridoma transfectants to
varying molar concentrations of VSV8 peptide pulsed onto R8
antigen presenting cells, are shown in red. The CDR3