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Figure 5.
Figure 5 (A) The surface representation of the complex shows
loop 3 of U1A (white) protruding through the hole in the RNA
internal loop (light blue); interactions involving Leu49, Ser46
and Ser48 (dark blue) and Arg52 (hidden in this orientation) are
critical to dock the protein against the RNA. (B) Surface
representation of free and bound protein structures. The red
surface identifies residues involved in intermolecular stacking
interactions that become exposed upon the rearrangement of helix
C; dark blue identifies loop 3 residues that interact with the
RNA by rigid fit; light blue identifies the location of the
remaining sites of intermolecular contact.
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