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Figure 5.
Model for oligomerization of the kinase domains of HER3 and
inactive HER4 at the plasma membrane. (A) Flexible C-terminal
tail/C-lobe interaction creates a possibility for the formation
of branched HER3 or inactive HER4 oligomers, resulting in a 2D
mesh. (B) Empirical estimates of binding free energy of the
HER3/HER4 N-lobe homodimer, calculated using conformations
obtained from an all-atom molecular dynamics simulation.
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