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Figure 5.
Effect of TMC353121 on HR1/HR2-peptide interaction. Schematic
representation of the different experimental conditions applied
in the 6HB-ELISA (A). Influence of different concentrations of
TMC353121 on the interaction between FITC-C39 with the HR1-CTC
(B). The bars present tha data generated with three different
experimental 6HB ELISA designs (orange = path 1; blue = path 2;
green = path 3). Interaction between FITC-C39 and the HR1-CTC in
the absence of TMC353121 was set at 100% (positive control), and
the relative HR2 interaction with the HR1-CTC in the other
conditions was normalized to this positive control condition.
Values are from three independent experiments. P values and 95%
confidence intervals are listed in Table S2.
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