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Figure 5.
Figure 5. Models for DegS Activation
(A) The
inhibition-relief model posits an equilibrium between free
inactive trimers (open squares) and free active trimers (open
circles). OMP peptides bind to both states (shaded circles or
squares) and shift the equilibrium toward the active form
because they bind more tightly to this conformation than the
inactive conformation.
(B) The peptide-activation model
posits that different OMP peptides stabilize slightly different
DegS conformations, in which the precise activity depends on the
identity of the penultimate side-chain of the bound peptide.
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