Figure 5.
Structural basis of H3-K(ac)14 binding to Brd4 BD1. A,
complex structure of the bromodomain 42–166 with the peptide
GGK(ac)A from H3 (green). B, hydrogen bonds between the H3
peptide and the essential asparagine Asn-140 in BD1 define the
interaction network. Several water molecules (colored red) in
the binding cavity of the bromodomain surround the acetyl moiety.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2009,
284,
36547-36556)
copyright 2009.
