|
Figure 5.
Model for the ring formation of the Nup84 complex. (A)
Schematic representation of the heptameric complex and the
approximate localization of its 7 nups (19). (B) The interaction
of Nup120 and Nup133 suggests the intermolecular interaction
between 2 heptamers in a head-to-tail fashion mediated by a
short stretch at the very N terminus of an extended unstructured
region of Nup133. (C) Eight heptamers are arranged in a closed
ring with a diameter of ≈1,000 Å in accordance with the
NPC dimensions determined by cryo-electron microscopy (8).
|
