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Figure 5.
Figure 5. 6-Position Derivatives Complexed to an Adenine
Binding RNA
(A) Structure of 6ClG bound to GRA; double
arrow represents a potential halogen bond between the chloro
group and U74.
(B) Binding pocket of the 6OMeG:GRA complex;
arrow denotes a long hydrogen bond (3.5 Å) between
N1(6OMeG) and N3(U74).
(C) Superposition of structures of
the wild-type hypoxanthine:GR complex (red), 6ClG:GRA (blue),
and 6OMeG:GRA (green). Most atoms in each structure superimpose
well, except for a minor repulsion between the ligand and U74 in
the 6OMeG:GRA complex to accommodate the methyl group at the
Watson-Crick interface.
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