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Figure 5.
Omit maps of inhibitors. F[o] – F[c] omit maps (magenta)
were calculated for the five inhibitors and contoured at the 2.0
σ level. The inhibitor and inhibitor-binding residues are shown
as ball-and-stick models with carbon atoms in green and gray.
The sulfur, nitrogen, and oxygen atoms are colored in yellow,
blue, and red, respectively. A and B, EPDTC bound to CVB3 3C^pro
and CoV-229E 3CL^pro. The zinc ion (cyan sphere) of EPDTC was
coordinated to the Cys and His residues. C and D, TG-0204998 in
covalent bond with the Cys of CVB3 3C^pro and SARS-CoV 3CL^pro.
E, TG-0205486 in covalent bond with the Cys of SARS-CoV 3CL^pro.
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