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Figure 5.
Figure 5. Flexibility of the Seh1•Nup85 Hetero-Octamer
(A) The hetero-octamers of crystal forms 1 and 2 are related by
an  vert,
similar 35° hinge motion around the center of the
hetero-octamer. On the right, a schematic of the two
conformations is shown, where Seh1 and Nup85 are displayed as
balls and cylinders, respectively.
(B) Crystal form 3
harbors a heterododecamer in the asymmetric unit (small ribbon
representation). The two interfaces between the heterotetramers
are identical. In the upper two neighboring heterotetramers of
crystal form 3 (boxed in the heterododecamer), one
heterotetramer is rotated by vert,
similar 80° around its long axis with respect to crystal
form 1. For clarity, a stripe of black lines marks the relative
orientations of the heterotetramers. The alignment of the
different structures was based on the lower heterotetramer of
crystal form 1.
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