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Figure 5.
Fig. 5. Lattice model for the Nup84 complex and the structural
scaffold of the NPC. The ACE1 proteins Nup85, Nup145C, Nup84,
Sec31, and Nic96 are colored according to Fig. 4. (A) Schematic
diagram of COPII outer coat organization. The Sec31  Sec13
cuboctahedron composed of 24 edge elements (Sec31 Sec13
heterotetramers) is shown unwrapped and laid flat in two
dimensions. The Sec31 Sec31 crown-crown
interactions make edge elements, whereas propeller-propeller
interactions are vertex elements (31). (B) Schematic diagram of
the predicted latticelike organization of the structural
scaffold of the NPC. The entire scaffold (eight spokes) is
illustrated unwrapped and laid flat in two dimensions. The Nup84
complex comprises the nuclear and cytoplasmic rings, whereas the
Nic96-containing complex makes up the inner ring. The relative
position and interactions between the seven proteins in the
Nup84 complex are shown with Sec13, Seh1, Nup133, and Nup120
colored in gray. The remainder of the Nic96 complex (Nup157/170,
Nup188, and Nup192) is illustrated in gray. The illustration is
not meant to predict relative positions of proteins or structure
of the inner ring per se but shows the latticelike organization
of the structural scaffold that is similar to vesicle coating
complexes.
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