|
Figure 5.
Schematic representation of the positioning of 25-D1.16 and
Hyb3 antibodies. 25-D1.16 and KB5-C20 TCR (11) utilize a very
similar mode of recognition of MHC-bound peptide that is
distinct from that used by Hyb3 antibodies (4). Red and green
vectors show virtually identical orientations of 25-D1.16 and
KB5-C20 TCR; the dark blue vector indicates a profoundly
different orientation of Hyb3; and the black vector indicates
peptide positioning in the binding groove of both H2-K^b and
HLA-A1 MHC-I proteins.
|
