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Figure 5.
Figure 5. Activation Loop Anchoring in Tyrosine Kinases
(A) The structure of the insulin receptor kinase domain (IRK)
bound to a substrate peptide is shown. The panel on the right
shows an enlarged view depicting the two anchor points and the
loops to which they form hydrogen bonds (shown as dashed lines).
(B) The activation loops from 12 structures of active
tyrosine kinases (see Experimental Procedures). The structures
were aligned on the catalytic loops, but only the activation
loops are shown.
(C) Hydrophobic interactions couple anchor
point 2 to the peptide-binding site. The structure of IRK is
shown. Residues of the substrate peptide that interact with the
hydrophobic residues are indicated.
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