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Figure 5.
The S4 helix. (A) Stereo side view of MlotiK1 and Kv1.2
S1–S4 domains superposed via S2 and S1. 3[10] regions in S4 of
MlotiK1 and Kv1.2 are shown in red and cyan, respectively. Other
TMs are represented by brown ribbons. S4 residues discussed in
the text are labeled. (B) Extracellular view of S1–S4 domains
from MlotiK1 and Kv1.2 superposed via S2 and S1. 3[10] regions
in S4 as in A. Other helical regions are in white ribbons. Kv1.2
R1, R2, R3, R4, K5, and R6 and equivalent MlotiK1 Cα atoms are
shown as blue and black spheres, respectively. (C) Surface
representation of MlotiK1 S1–S4 domain. S4 is shown as a red
ribbon, with residues equivalent to R2, R3, R4, K5, and R6 shown
as sticks. Protein regions from S1 to S3 are shown as gray
surface representations. S1, S2, and S3 helices are shown as
green ribbons inside the surface. (D) Same as in C but viewed
from the extracellular side.
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