Figure 5.
The mutated residues, NL1 Asp106 (corresponding to the NL4
G99S mutation), NL1 Lys414 (corresponding to the NL4 K378R
mutation), NL1 Arg473 (corresponding to the NL3 R451C mutation)
and NL1 Val439 (corresponding to the NL4 V403M mutation), are
colored green and shown in space-filling representation, and are
mapped on the NL1–NX1 complex
(ribbons). These residues are away from the binding and
dimerization interfaces, and are mostly buried.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2008,
15,
50-56)
copyright 2008.
complex
(ribbons). These residues are away from the binding and
dimerization interfaces, and are mostly buried.