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Figure 5.
FIGURE 5. X-ray structure of AM7 bound to c-Met. A,
overview of complex. AM7 is shown in yellow, activating c-Met
mutations are shown in pink, and side chains of interest are
colored blue. Activating mutation M1250T is below the field of
view and so is not shown. At its closest approach to AM7 it is
still 18 Å removed from AM7. Activating mutations D1228H
and Y1230H are located in the activation loop, which is
disordered in this structure. B, experimental f[o] - f[c]
electron density contoured around AM7 at 2.5  .
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