|
Figure 5.
Figure 5. V[NAR]-AMA1 Contacts
(A) Alignment of AMA1s
from P. falciparum strains 3D7, W2mef, and HB3 (residues
N104–E438). Residues polymorphic between strains are boxed.
Conserved hydrophobic cleft residues are underlined and
asterisked. Residues in contact with V[NAR]s 14I-1 and 14I1-M15
(magenta), 14I-1 only (red), or 14I1-M15 only (blue) are
indicated.
(B) Stereo images of the 14I-1 backbone (red)
penetrating the AMA1 hydrophobic cleft (gray). Side chains of
AMA1 residues within 4 Å of the V[NAR] backbone are shown,
including hydrophobic residues forming the base of the
hydrophobic cleft (orange) and residues polymorphic between P.
falciparum strains 3D7, W2mef, and HB3 (cyan).
(C) As for
(B) except for 14I1-M15 backbone (blue).
|
