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Figure 5.
Figure 5. Survival of Mice Intragastrically Infected with
Lmo-EGD and Lmo-InlA^m and Associated Bacterial Organ Loads over
Time
Survival curves (A) and organ loads (B–F) of female
C57BL/6J mice inoculated intragastrically with Lmo-EGD (dashed
curve, ○) or Lmo-InlA^m (solid curves, ●). (A) shows that
Lmo-InlA^m exhibit more than 1000-fold higher virulence than
wild-type Lmo-EGD (inocula as indicated, n = 10 for each
bacterial strain and experiment). (B–F) shows that 1 ×
10^10 bacteria of either strain were administered
intragastrically to analyze kinetics of bacterial growth (n = 6
for 24 h p.i. and n = 12 for all others). Organ loads were
ascertained at five time points in the stomach (B), small
intestine (C), mesenteric lymph nodes (D), spleen (E), and liver
(F). All data are from two independent experiments. The bar
represents the median for each time point and genotype; 95%
confidence intervals are indicated. Statistical significance by
Mann-Whitney U nonparametric test: ^*p < 0.05, ^**p < 0.01, and
^***p < 0.001.
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