Figure 5.
FIGURE 5. HADDOCK-derived model for the Npl4 UBD-p97 N
complex. A, C[ ]traces representing
the super-position of the 10 refined Npl4 UBD-p97 N complex
structures using the HADDOCK approach. B, ribbon representation
of the Npl4 UBD (pink)-p97 N (blue) complex. C, ribbon
representation of the p47 UBX (gold)-p97 N (blue) complex. The
coordinates for the p47 UBX-p97 N complex are taken from PDB
accession number 1S3S (20). D, close-up view of key interacting
side chains shown in stick representation. E, close-up view of
residues in Npl4 UBD, which, when mutated by Bruderer et al.
(15), abolished binding to p97 N domain.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2007,
282,
21361-21369)
copyright 2007.
]traces representing
the super-position of the 10 refined Npl4 UBD-p97 N complex
structures using the HADDOCK approach. B, ribbon representation
of the Npl4 UBD (pink)-p97 N (blue) complex. C, ribbon
representation of the p47 UBX (gold)-p97 N (blue) complex. The
coordinates for the p47 UBX-p97 N complex are taken from PDB
accession number 1S3S (20). D, close-up view of key interacting
side chains shown in stick representation. E, close-up view of
residues in Npl4 UBD, which, when mutated by Bruderer et al.
(15), abolished binding to p97 N domain.