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Figure 5.
Figure 5 Possible fibrillogenesis mechanism: FN molecules exist
in solution, with the ^1-2FNIII domain pair in closed
conformation, likely interacting with the FN N-terminus as part
of a larger globular structure (A). Under tension, the FN
globular structure and the ^1FNIII–^2FNIII interaction are
disrupted (B, C). This allows the ^1-2FNIII open conformation to
strongly associate with the N-terminus of other FN molecules (C)
and, along with the disulfide crosslinks at the FN C-terminus,
create FN fibrils. The different domain types of FN are shown in
gold (FNI), purple (FNII) or cyan (FNIII). The different FN
fragments shown correspond to: FN30 kDa, ^1-5FNI; gelatin
binding domain, ^6FNI-^1-2FNII-^7-9FNI.
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