Figure 8 - full size

 

Figure 8.
Figure 8. Aromatic interactions observed between Phe140 and His163 in the crystal structures of SARS-CoV M^pro (wild type and variants). The broken lines indicate the alignment of the partial positive charges (δ+) of the hydrogen atoms on the phenyl ring of Phe140 with the partial negative charges (δ−) in the central part of the imidazole ring of His163.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2007, 366, 916-932) copyright 2007.