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Figure 5.
Structure of the Lingo-1 tetramer. A, view of the top and
front surfaces of the Lingo-1 tetramer, rendered in red, green,
magenta, and yellow. The two views are related by a 90°
rotation about the horizontal axis. Carbohydrate are shown as
yellow sticks. The LRR modules interlock the ring head-to-tail,
back-to-back, with the IgI1s extend vertically. The bottom view
illustrates the putative orientation of the tetramer relative to
a cell surface. B, detailed view of molecular interfaces. The
imprint of bound LRR (red ribbons) on the molecular surface of a
neighboring monomer is colored blue. The top and bottom insets
are close-up views of some of the interactions at the LRR-LRR′
and IgI1-LRR′ interfaces, respectively; the prime symbols
denote the partner molecule. Molecular surfaces for the two
interacting monomers are colored as in A, green and red. Side
chains of interacting residues are shown as a ball-and-stick
model, and hydrogen bonds are shown with dashed white lines. All
interface residues are conserved apart from Ala^461 (Ser in
chicken, see also Fig. 7A).
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