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Figure 5.
FIGURE 5. Surface representations of the SH3 domains from
Crk-N complexed with C3G peptide, Abl complex with 3BP1, and
srGAP1. The views on the left depict surface accessible
hydrophobic regions colored in yellow. On the right are
representations of electrostatic potential showing the peptide
binding surface of the SH3 domains with the n-Src loops pointing
toward the top, in which the positive electrostatic potential is
colored in blue, negative electrostatic potential is colored in
red, and hydrophobic surface is colored white. Peptides are in
ball-and-stick representation. Coordinates for the SH3 domains
of Crk-N and Abl were obtained from the Protein Data Bank. In
the surface of the SH3 domain of srGAP1, the red circles
indicate the four pockets in the ligand binding groove. The
figure was produced by CCP4mg and PyMOL.
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