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Figure 5.
Figure 5. Hydrogen bonding and thioester integrity. (a) The
main chain hydrogen bond pattern around the thioester in bovine
C3. Except for the thioester, only main chain atoms are shown.
Hydrogen bonds from the carbonyl group of Met1014 to the amide
groups of either Met1017 or Thr1018 appear to be almost equally
favorable. (b) The same area in C3d. In this structure (RCSB
entry 1C3D), a Cys1010Ala mutant was used. (c) The hydrogen bond
patterns in native human C3 (RCSB entry 2A73) around the
thioester in the same orientation as in (a). (d) The hydrogen
bond pattern of human C4Adg (RCSB entry 1HZF) in the same area.
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