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Figure 5.
FIGURE 5. Determinants of PDZ domain specificity. The
structure of ZO1-PDZ1-YL is shown schematically and colored to
highlight the functional elements involved in ligand
recognition. The peptide ligand is colored green (core motif)
and yellow (auxiliary motif). The PDZ domain functional elements
are colored magenta (primary), red (secondary), and blue
(tertiary). The spheres indicate key side chains of the PDZ
domain that contribute to recognition of side chains within the
core ligand motif.
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